Fig. 8
From: Mesangial cells are key contributors to the fibrotic damage seen in the lupus nephritis glomerulus
Expression of mRNA for ECM genes by conditionally immortalised mesangial cells following cytokine stimulation with TGF-β1 receptor blockade. Conditionally immortalised MCs were treated with SB-431542 for 30 mins before stimulation with a combination of TNF-α, IL-1β, IFN-α and IFN-γ. mRNA expression was assessed for COL1A1 (a), COL1A2 (b), COL4A1 (c), LAMB1 (d), MMP9 (e) and TIMP1 (f). N = 5 per group, data are analysed using Friedman’s test with Dunn’s post-hoc test, *P < 0.05 and **P < 0.01 vs untreated MCs