Fig. 1

Effect of the preconditioning with different doses and concentrations of NaCl 7,5% in endotoxemic animals. A- Animals were separated in 4 groups – LPS (received a lethal dose of LPS 15 mg/kg i.p); HS2 (received 3 doses in alternated days of 2 mL/kg of NaCl 7.5% and a lethal dose of 15 mg/kg of LPS at the 8th day of the study); HS4 (received 3 doses of 4 mL/kg of NaCl 7.5% and a lethal dose of 15 mg/kg of LPS at the 8th day of the study); HS8 (received 4 mL/kg at day one, 6 mL at day 3 and 8 mL/kg at day 5 and a lethal dose of 15 mg/kg of LPS at the 8th day of the study). *p < 0,05 vs LPS; were used 20 animals for each group. B- Animals were separated in 5 groups – LPS (received a lethal dose of LPS 15 mg/kg i.p); HS7.5% (received 4 mL/kg at day one, 6 mL at day 3 and 8 mL/kg at day 5 and a lethal dose of 15 mg/kg of LPS at the 8th day of the study); HS3.5% (received 4 mL/kg at day one, 6 mL at day 3 and 8 mL/kg at day 5 and a lethal dose of 15 mg/kg of LPS at the 8th day of the study); NS0.9% (received 4 mL/kg at day one, 6 mL at day 3 and 8 mL/kg at day 5 and a lethal dose of 15 mg/kg of LPS at the 8th day of the study); and HM20% received 20% mannitol (received 4 mL/kg at day one, 6 mL at day 3 and 8 mL/kg at day 5 and a lethal dose of 15 mg/kg of LPS at the 8th day of the study). *p < 0,05 vs LPS; were used 20 animals for each group