Table 3 Genetic modifications of the organ-source pig that may be protective against the inflammatory response

Hemeoxygenase-1 (HO-1)

anti-inflammatory,

anti-apoptotic

[14, 172,173,174,175,176,177,178]

A20 (tumor necrosis factor-α-induced protein)

anti-inflammatory,

anti-apoptotic

[179,180,181]

Thrombomodulin (TBM)

anticoagulation,

anti-inflammatory

[182,183,184,185,186,187]

Endothelial protein C receptor (EPCR)

anticoagulation,

anti-inflammatory

[188]

Ectonucleoside triphosphate diphosphohydrolase-1 (CD39)

anticoagulation,

anti-inflammatory

[189,190,191]

Tissue factor pathway inhibitor (TFPI)

anticoagulation,

anti-inflammatory

[192, 193]