Evidence for the important role of inflammation in xenotransplantation

Journal of Inflammation

Table 1 Evidence for systemic inflammation in xenograft recipients (SIXR)

	Indicators of inflammation	Change when associated with xenotransplantation	References
In vivo	C-reactive protein (C-RP)	↑	[13, 19, 26]
	Serum amyloid A (SAA)	↑	[26,27,28]
	Histones	↑	[26]
	D-dimer	↑	[6, 13, 19]
	Tumor necrosis factor-alpha (TNF-α)	↑	[18]
	Interferon-gamma (IFN-γ)	↑	[18]
	Interleukin-6 (IL-6)	↑	[13, 18]
	Interleukin-8 (IL-8)	↑	[13, 18]
	Interleukin-12 (IL-12)	↑	[18]
	Monocyte chemotactic protein-1 (MCP-1)	↑	[13, 18]
	Soluble CD40 ligand (sCD40L)	↑	[13, 29]
	Free triiodothyronine (fT3)	↓	[6, 30]
In vitro	Platelet aggregation	↑	[26]
In vitro	Endothelial cell apoptosis	↑	[26]

ISSN: 1476-9255