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Fig. 5 | Journal of Inflammation

Fig. 5

From: Evidence for the important role of inflammation in xenotransplantation

Fig. 5

a Changes in the levels of selected serum cytokines after pig-to-baboon artery patch transplantation (n = 8) (i) TNF-α; (ii) IFN-γ; (iii) MCP-1. In baboons (n = 3) that did not receive immunosuppressive therapy after artery patch transplantation, levels of (i) TNF-α, (ii) IFN-γ, and (iii) MCP-1 were significantly higher on post-transplant days 14 and 28 than pre-transplant. When full immunosuppressive therapy was administered to the baboons (n = 5), no increase in any of the three cytokines was observed. (Reprinted with permission from ref. [18]). b Changes in the levels of selected cytokines after pig-to-baboon kidney (n = 3) or heart (n = 2) transplantation. (i) TNF-α; (ii) IFN-γ; (iii) MCP-1. Although the numbers of experiments were small, (i) TNF-α and (iii) MCP-1 were significantly higher in kidney recipients (*P < 0.05), but not in heart recipients. (ii) IFN-γ was not significantly increased in recipients after kidney or heart transplantation. (Reprinted with permission from ref. [18])

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