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Table 2 Distribution of SNP variations among study participants - Additive model

From: SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren’s syndrome

SNP

Risk Allele

SSa (n = 82) n (%)

DESb (n = 98) n (%)

P (χ2)

CEUc Freq. (HapMap)

TNFα (rs1800629)

G

Homozygote G

58 (70.8)

83 (84.7)

67.3

 
 

Heterozygote

22 (26.9)

11 (11.2)

31

 

Homozygote A

1 (1.3)

2 (2.1)

1.8

 
 

0.02

  

IL10 (rs1800896)

A

Homozygote G

13 (15.9)

21 (21.4)

27.4

 
 

Heterozygote

36 (44.0)

42 (42.9)

51.3

 

Homozygote A

32 (39.1)

35 (35.7)

21.2

 
 

0.64

  

TNFAIP3 (rs2230926)

G

Homozygote T

73 (89.2)

85 (86.7)

94.7

 
 

Heterozygote

8 (9.8)

10 (10.3)

5.3

 

Homozygote G

0

0

0

 
 

0.54

  
  1. a- ss (Sjogren’s Syndrome); b − DES (Dry Eye Syndrome)
  2. c − CEU (C): Utah residents with Northern and Western European ancestry from the CEPH collection. Data is available at Hapmap
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Journal of Inflammation

ISSN: 1476-9255

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