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Fig. 1 | Journal of Inflammation

Fig. 1

From: Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone

Fig. 1

Acidic pH-induced CXCL8 protein secretion and mRNA expression in ASMC. a CXCL8 is produced by extracellular acidification in ASMCs. ASMCs generate CXCL8 protein by extracellular acidification in a time-dependent manner. Data are expressed as percentages of CXCL8 values obtained at pH 6.3 for 24 h (mean ± SEM, n = 3; **, P < 0.01; *, P < 0.05 compared with pH 7.4). b CXCL8 secretion is significantly increased at pH 6.3 compared with that at pH 7.4. Data are expressed as percentages of CXCL8 values obtained at pH 7.4 for 24 h (mean ± SEM, n = 4; **, P < 0.01). c CXCL8 mRNA expression is increased until 5 h after pH 6.3 stimulation. The expression levels of CXCL8 mRNA are standardized to those of GAPDH mRNA. Data are expressed as percentages of CXCL8 mRNA expression at 5 h after pH 6.3-stimulation (mean ± SEM, n = 3; **, P < 0.01)

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Journal of Inflammation

ISSN: 1476-9255

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