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Fig. 2 | Journal of Inflammation

Fig. 2

From: Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis

Fig. 2

Assessment of synovitis and macrophage infiltration. a-c. Representative sections of the synovium stained with hematoxylin and eosin. Control (a), AIA (b) and AIA + TOFA (c). Scale bar = 100 μm. d-i. Immunohistochemistry of representative sections of the synovium using the monoclonal anti-rabbit macrophage antibody RAM11. Control (d, g), AIA (e, h), AIA + TOFA (f, i). Scale bar (d-f) = 100 μm. Arrows point to representative crown-like structures (h, i) which are surrounded by a line, scale bar (g-i) = 25 μm. j. Global synovitis score. Bars show the mean and SEM (n = 16 paws per group). *p < 0.05 vs. Control, #p < 0.05 vs. AIA. k. Densitometric analysis of RAM11 staining percentage in the synovium of each group of animals. Data is shown as the mean and SEM (n = 16 paws per group).*p < 0.05 vs. Control.AIA: antigen induced arthritis; TOFA: tofacitinib

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