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Fig. 6 | Journal of Inflammation

Fig. 6

From: The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation

Fig. 6

Presumptive mechanism of CD200–CD200R1 interaction between neurons and microglia. CD200 bind CD200R1 through N-terminal amino acid, leading to the activation of CD200R. The tyrosine residues of CD200R recruits DOK2 and RasGAP, ultimately resulting in the inhibition of Ras activation and reduce of multiple anti-inflammatory signals. Blocked interaction by N44Q mutant inhibits the signaling of CD200R inactivates downstream proteins, leading to the increase of multiple pro-inflammatory signals under LPS stimulation. P: Phosphotyrosine

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