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Fig. 6 | Journal of Inflammation

Fig. 6

From: Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Fig. 6

Diagram of the signaling cascade involved in the effect of TRPA1-mediated Ca2+ influx on apoptosis in IL-1β-induced rat chondrocytes. IL-1β caused increased functional expression of TRPA1, which contributed to massive Ca2+ influx. Due to cytosolic calcium overload, the mitochondrial membrane potential is significantly reduced, leading to the activation of the intrinsic pathway of apoptosis in rat chondrocytes. TRPA1 transient receptor potential ankyrin 1, IL interleukin, Cyto cytochrome

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