Fig. 4

Pyroptosome formation in the cortex and hippocampus of aged mice: Aging induces laddering of ASC in cortex (a) and hippocampus (b) of mice, indicating formation of the pyroptosome, an oligomerization of ASC that leads to pyroptosis. Representative immunoblot and quantification of gasdermin-D in the cortex (c) and hippocampus (d) of aged mice when compared to young. Gasdermin-D is significantly elevated in the cortex and hippocampus of aged mice. Data presented as mean+/-SEM. N = 5 per group. * p < 0.05