Skip to main content

Table 1 Demographic, clinical and laboratory variables of patients with UC and controls

From: Caspase recruitment domain (CARD) family (CARD9, CARD10, CARD11, CARD14 and CARD15) are increased during active inflammation in patients with inflammatory bowel disease

VARIABLES ACTIVE UC (n = 26) REMISSION UC (n = 22) CROHN’S DISEASE (n = 10) CONTROL GROUP (n = 18)
Age
 Mean ± SD (years) 37.7 ± 10.5 39.0 ± 13.7 45.2 ± 19.7 47.7 ± 11.4
 Median 38 35 41 52
 Range 20–57 20–66 21–85 24–60
Gender
 Female (%) 13 (50) 12 (55) 2 (20) 11 (61)
 Male (%) 13 (50) 10 (45) 8 (80) 7 (39)
Clinical course
 Relapsing-remitting (%) 80.7 22.7 0 NA
 Remission (%) 15.3 77.2 87.5 NA
 Continuous activity (%) 3.8 0 12.5 NA
 Extra intestinal manifestations (%) 64 27.2 33 NA
Disease duration
 Mean ± SD (years) 6.03 ± 4.96 11.59 ± 6.7 7.2 ± 8.8 NA
 Median 4.5 11.5 5.5 NA
 Range 0–19 1–30 0–27 NA
Treatment
 5-aminosalycilates (%) 38.5 54.5 50.0 NA
 5-aminosalycilates + steroids (%) 61.5 45.5 50.0 NA
 Steroid dependent (%) 3.8 0.0 12.5 NA
 Steroid resistant (%) 23.0 18.2 12.5 NA
Histopathology severity
 Inactive disease (%) 0 100 11 NA
 Mild (%) 28 0 89 NA
 Moderate (%) 24 0 0 NA
 Severe (%) 48 0 0 NA
 Dysplasia (%) 0 0 0 NA
Laboratory values
 Hemoglobin (g/dL), Mean ± SD 12.9 ± 2.9* 14.3 ± 1.4 13.9 ± 2.1 14.8 ± 1.8
  Median 13.6 14.6 14.4 14.9
  Range 5.6–18.3 10.7–16.4 8.9–16.5 10.6–17.6
 Mean corpuscular volume (fL), Mean ± SD 83.4 ± 8.1 88.5 ± 5.0 89.2 ± 7.3 90.2 ± 5.3
  Median 85.2 89.0 91.4 91.1
  Range 62.3–93.9 79.5–98.1 72.0–96.3 73.5–95.7
Mean corpuscular hemoglobin (pg/cell),
  Mean ± SD 27.5 ± 3.3 30.0 ± 2.2 30.2 ± 2.6 30. 7 ± 2.2
  Median 28.5 30.4 30.4 31.2
  Range 20.2–31.8 25.8–33.8 24.0–32.9 23.6–33.2
 Leukocytes (103/μL), Mean ± SD 8.3 ± 2.5 6.8 ± 2.7 6.6 ± 3.1 7.0 ± 2.3
  Median 8.6 6.2 5.5 6.6
  Range 3.7–13.9 4.6–17.4 4.2–14.7 3.4–13.1
 Neutrophils (%), Mean ± SD 62.5 ± 12.2 63.2 ± 8.5 70.5 ± 10.4 58.0 ± 9.7
  Median 63.2 61.6 70.3 59.8
  Range 35.0–85.0 46.6–81.2 53.4–91.0 39.4–75.6
 Lymphocytes (%), Mean ± SD 26.5 ± 9.9 27.4 ± 8.3 20.5 ± 8.9 30.6 ± 9.4
  Median 26.4 27.6 18.3 27.5
  Range 10.0–44.0 14.8–44.5 6.6–35.4 15.2–50.5
 Monocytes (%), Mean ± SD Median 7.9 ± 2.6 7.1 ± 2.2 7.9 ± 3.5 7.4 ± 1.8
  Median 7.8 6.8 7.5 7.3
  Range 3.9–12.8 2.5–11.1 1.8–14.5 3.7–11.0
 Platelets units 103/μL), Mean ± SD 375.3 ± 142.0 238.0 ± 89.7 183.4 ± 58.1 212.2 ± 70.0
  Median 371.0 229.0 187.0 207.0
  Range 155.0–869.0 68.0–436.0 94.0–227.0 105.0–325.0
 Erythrocyte Sedimentation Rate (mm/h),
  Mean ± SD 23.6 ± 18.8 13.1 ± 12.0 8.0 ± 6.9 3.5 ± 1.9
  Median 17.5 11.0 4.0 3.0
  Range 2.0–66.0 2.0–46.0 2.0 - 19.0 2.0–6.0
Environmental exposure
 Tobacco (%) 54.0 72.3 44.4 22.2
 Alcohol (%) 35.0 31.8 22.2 16.6
Comorbidities
 Allergies (%) 3.8 9 0 16.6
 Autoimmune diseases (%) 3.8 13.6 11.1 16.6
Medical history
 Hypertension (%) 0 4.5 0 22.2
 Overweight/obesity (%) 0 0 0 5.5
 Diabetes (%) 0 0 11.1 11.1
 Dyslipidemia (%) 0 4.5 0 22.2
 Gynecologic diseases (%) 3.8 18.1 0 16.6
 Surgery history (%) 61.5 68.1 55.5 55.5
  1. CD crohn’s disease, UC ulcerative colitis
  2. Hemoglobin p = 0.018 (active ulcerative colitis vs. control group)
  3. Mean corpuscular volume p = 0.008 (active ulcerative colitis vs. control group) and p = 0.048 (remission ulcerative colitis vs. control group) Neutrophils p < 0.001 (Crohn’s disease vs. control group)
  4. Erythrocyte sedimentation rate p = 0.042 (active ulcerative colitis vs. control group) and p = 0.0498 (active ulcerative colitis vs. Crohn’s disease)
  5. Non-parametrical tests were used such as U Mann Whitney test for numerical variables and Fisher Exact test for categorical variables