Fig. 1

Effect Atorvastatin and Diacerein survival in CLP sepsis model. Male Wistars rats, 8 weeks old, received saline (Sham/Sal, n  =  20), (Sepsis/Sal, n  =  20) or atorvastatin 10 mg/kg (Sepsis/Ator, n  =  20), or diacerein 100 mg/kg (Sepsis/Diac n  =  20) 3 h after surgery and once a day following CLP. Survival of the rats was monitored at intervals of 4 h for 1-week, than every 12 h until day 15. The overall difference in survival rate between the groups with and without atorvastatin was significant (P < 0.0001). The overall difference in survival rate between the groups with and without diacerein was significant (P < 0.0001) (a). Fasting blood glucose (b). Glucose disappearance rate (c). Serum levels of IL-6 (d) and TNF-α (e). Data are presented as means ± SEM of six rats per group (except for survival curve). *P < 0.05 (Sepsis saline vs. all others groups)