Fig. 4

Effect of zymosan treatment (Z) on TNF-α, TLR-2 and TLR-4 genes expression in mouse peritoneal macrophages in melanoma-bearing (M) mice. The expression of TNF-α (black bars), TLR-2 (grey bars) and TLR-4 (lined bars) mRNA in M, Z and zymosan-treated (10 μg, i.p.) melanoma-bearing (ZM) mice was determined relative to that in control mice. Results are presented as means ± SD of n = 5 animals per group. ⁺P < 0.05 compared with M mice, *P < 0.05 compared with ZM mice, ^#P < 0.05 compared with control mice