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Fig. 6 | Journal of Inflammation

Fig. 6

From: Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model

Fig. 6

IL-10 attenuated the TNF-α-induced down-regulation of claudin-5 and impairment of tight junctions among BMECs. A. Immunofluorescence staining of claudin-5 (green) on BMECs; the nuclei were stained with DAPI (blue). Scale bar represents 10 μm. Control group showed continuous, linear, smooth peri-cellular tight junctions between BMECs. Tight junctions were extremely disrupted following TNF-α treatment. IL-10 alleviated the impairment of tight junctions induced by TNF-α. B. Representative WB images showing claudin-5 protein expression levels in BMECs (a). WB analysis of claudin-5 expression (n = 3, b). * p < 0.05 (t-test), versus the control group, # p < 0.05 (t-test), versus the TNF-α treatment group

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