Fig. 1

IL-10 alleviated the severity of inflammation and increased BBB permeability in SAP rats. a Representative images of H&E-stained rat pancreases (× 200). No significant pathological changes were observed in the pancreases of the control group (i). The pancreases of the SAP group exhibited obvious pancreatic edema, hemorrhage and necrosis as well as inflammatory cell infiltration (ii). Milder impairment of the pancreas was observed in the IL-10 treatment group than in the SAP group (iii). b Pancreatic pathological scores (n = 8). c Serum amylase levels (n = 8). d Serum TNF-α levels (n = 8). E. Evan’s blue assay (n = 8). * p < 0.001 (t-test), versus the control group, # p < 0.05(t-test), versus the SAP group