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Fig. 2 | Journal of Inflammation

Fig. 2

From: Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression

Fig. 2

Overexpression of HDAC2 attenuates LPS-induced PAI-1, TNF, and MIP-2 secretion, but enhances uPA secretion. RAW264.7 cells were transfected with HDAC2 expression vector for 48 h, and then stimulated with 100 ng/ml LPS for 2 h. HDAC2 overexpression resulted in a 1.5-fold increase in protein levels of HDAC2 (a). HDAC2 inhibited LPS-induced secretion of PAI-1 (b), TNF (c), and MIP-2 (d), but increased uPA secretion (e). Data are expressed as the mean relative expression ± SEM of at least three independent experiments

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