Fig. 8

The effect of tofacitinib, dosed orally (15 mg/kg BID, with accompanying intracecal vehicle dosing) or intracecally (1 mg/kg BID, with accompanying oral vehicle dosing) on the number of NK cells in the spleen. Each control mouse received both oral and intracecal vehicles. The mean values (± SEM) for each treatment group are shown (n = 9 or 10). **** p < 0.0001 vs. Vehicle (One-way ANOVA, Fisher’s post-hoc test). Representative flow cytometry plots of splenic lymphocytes (NK cells circled) are also shown