Fig. 7

Representative images of colons from mice treated intrarectally with ethanol, and then challenged with vehicle or IFNγ, and stained immunohistochemically with a monoclonal antibody to pSTAT1. Mice were pretreated orally with vehicle followed by intrarectal vehicle (a), or IFNγ (b), or with tofacitinib (60 mg/kg orally) followed by intrarectal IFNγ (c). pSTAT1 is visually represented by the dark staining. The colon is coiled in a “Swiss roll” configuration