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Table 1 Baseline characteristics and outcomes

From: Treatment with 24 h–delayed normo- and hyperbaric oxygenation in severe sepsis induced by cecal ligation and puncture in rats

  Control (n = 18) NBO2 (n = 18) HBO2 (n = 19) P-value
Weight, gram (SD) 296 (24) 281 (14) 309 (25) < 0.0001
Temp. at beginning of OP, C° (SD) 36.2 (0.7) 36.4 (0.9) 36.2 (0.6) 0.54
Temp. at end of operation, C° (SD) 36.7 (0.6) 36.4 (0.4) 35.4 (0.4) 0.97
Operation time, minutes (IQR) 50 (45–58) 47 (34–56) 50 (40–64) 0.37
Caecum ligated, millimeters (SD) 62.9 (6.7) 60.8 (6.5) 60.3 (6.8) 0.81
Microorganisma
 Positive blood culture 4 (57) 4 (44) 9 (82) 0.16
 Polymicrobial 2 (29) 3 (33) 3 (27) 0.77
Escherichia coli 4 (57) 3 (33) 6 (55) 0.41
 Enterococcus faecalis 1 (14) 3 (33) 2 (18) 0.62
 Other 2 (29) 3 (33) 4 (36) 0.89
Cytokinesb, pg/mL
 TNF-α 57.2 (0.4–114.9) 11.9 (0.4–118.7) 25.7 (0.4–102.9) 0.99
 IL-6 33.4 (2.8–70.0) 2.8 (2.8–153.2) 2.8 (2.8–30.5) 0.87
 IL-10 79.4 (0.1–155.9) 0.1 (0.1–278.8) 64.7 (0.1–148.5) 0.66
Blood drawn sublinguallyc
No of subjects 7 (17) 10(22) 9(17)  
Mortality
 24-h 6 (33) 8 (44) 4 (21) 0.13
 48-h 10 (56) 9 (50) 8 (42) 0.63
 72-h 11 (61) 9 (50) 8 (42) 0.63
  1. CLP cecal ligation and puncture, NBO 2 normobaric oxygen, HBO 2 hyperbaric oxygen, Temp. temperature, IL interleukin, TNF tumor necrosis factor, SD standard deviation, IQR interquartile range, OP operation
  2. Differences between the NBO and HBO groups were tested using Chi-square test/Fisher’s exact test, student’s unpaired t-test or Mann-Whitney U-test
  3. aBlood sampling on rats alive at time = 72 h (control n = 7; NBO n = 9; HBO n = 11). Values are reported as number of subjects (%)
  4. bBaseline cytokine concentrations taken after CLP procedure at time = 0 h. Values are reported as mean (IQR)
  5. cNo of samples drawn sublingually. In total 26 of 117 cases, the femoral vein catheter was obstructed. Values are reported as number of subjects (%)