Detection of circulating natural antibodies to inflammatory cytokines in type-2 diabetes and clinical significance

Table 3 Binary regression analysis of circulating IgG against inflammatory cytokines in T2D

Antigens	Patient (n)	Control (n)	Adjusted r ²	p ^a
IL1α
Male	1.15±0.42 (124)	1.21±0.39 (131)	-0.002	0.228
Female	1.20±0.43 (76)	1.32±0.39 (89)	0.009	0.083
Combined	1.17±0.42 (200)	1.26±0.39 (220)	0.012	0.04
IL1β
Male	0.70±0.28 (124)	0.77±0.30 (131)	0.019	0.04
Female	0.78±0.31 (76)	0.80±0.33 (89)	-0.01	0.788
Combined	0.73±0.29 (200)	0.78±0.31 (220)	0.011	0.07
IL6
Male	1.13±0.21 (124)	1.18±0.19 (131)	0.01	0.038
Female	1.11±0.23 (76)	1.24±0.22 (89)	0.065	0.0008
Combined	1.12±0.22 (200)	1.20±0.21 (220)	0.034	0.0001
IL8
Male	0.97±0.35 (124)	1.02±0.29 (131)	0.003	0.134
Female	0.94±0.33 (76)	1.12±0.35 (89)	0.056	0.003
Combined	0.96±0.34 (200)	1.06±0.32 (220)	0.021	0.002
TNF-α
Male	0.77±0.40 (124)	0.95±0.60 (131)	0.024	0.005
Female	0.85±0.48 (76)	0.95±0.45 (89)	-0.002	0.226
Combined	0.80±0.43 (200)	0.95±0.54 (220)	0.017	0.003

Data were expressed as mean±SD. ^aAdjusted for age in male and female samples, and for gender and age in combined samples.

ISSN: 1476-9255