Table 3 Differential expression of genes from injured lung tissue in comparison control non-injured lung tissue

NM_001047130

IL2

Interleukin 2

T-cell activation and proliferation, B-cell, NK cell, and monocyte activation

XM_001093307

SPP1

Secreted phosphoprotein 1

Upregulation of inflammatory cytokines including IL-12 and Interferon Gamma

XM_001110657

CXCL14

Chemokine (C-X-C motif) ligand 14

Chemotactic for monocytes

MIP-2γ

XM_001095645

MAL

Mal, T-cell differentiation protein

Endoplasmic reticulum protein likely associated with T-cell signal transduction

XM_001103106

PRG3

Proteoglycan 3

Stimulates neutrophil respiratory burst and IL-8 production, as well as basophil histamine and leukotriene C4 production.

XM_001101685

KNG1

Kininogen 1

Part of kallikrein blood coagulation and can be cleaved to produce bradykinin

XM_001092700

FGF10

Fibroblast growth factor 10

Involved in wound healing, and secreased by alveolar epithelial cells in response to injury.

XM_001094451

LBP

Lipopolysaccharide binding protein

Acute phase reactant to gram-negative bacteria and facilitates LPS binding to CD14 on monocytes.

XM_001108113

IFNW1

Interferon, omega 1

Involved in Toll-Like receptor Signaling Pathways and Type I interferon receptor binding.

XR_092351

LOC100426120

BCL2/adenovirus E18 19 kDa protein interacting protein 3-like

BCL2 – Suppresses apoptosis by regulating mitochondrial membrane permeability and inhibits caspase activity.

XM_001112015

LTA

Lymphotoxin alpha (TNF superfamily, member 1)

Member of TNF family and mediates various inflammatory, immunostimulatory, and antiviral responses.

XM_001100604

BNIP2

BCL2/adenovirus E1B 19kDa interacting protein 2

Inhibits cell death

XM_001110285

BCL2L1

BCL2-like 1

Regulates mitochondrial release of apoptotic factors

NM_001032946

CCL23

Chemokine (C-C motif) ligand 23

Potent chemotactic factor for monocytes, resting T-cells, and neutrophils.

MIP-3

XM_001107576

IFNA14

Interferon, alpha 14

Binds type interferon receptor and demonstrates anti-viral activity

XM_001107510

IL1R1

Interleukin 1 receptor, type I

Mediates IL-1 dependent activation of NF-kappa-B and MAPK pathways.

XM_001087874

LOC699418

Eosinophil lysophospholipase-like

Protecgt eosinophils from being lysed by large amounts of phospholipids

XM_001117159

IL22

Interleukin 22

Part of IL-10 family and initiates innate immune responses against bacteria in gut and respiratory epithelial cells.

XM_001110530

S100A8

S100 calcium binding protein A8

Involved in cell cycle progression and differentiation intracellularly as well as neutrophil chemotaxis, proinflammatory, pro-apoptotic, DAMP, and oxidant-scavening

XM_001108108

IL18RAP

Interleukin 18 receptor accessory protein

Enhances IL-18R signaling though PEDF induced signaling.

XM_00108022

PROK2

Prokineticin 2

Involved in circadian rhythm and gastrointestinal smooth muscle contraction.

XM_001113239

IL22RA1

Interleukin 22 receptor, alpha 1

Part of IL-10 receptor complex and induces JAK/STAT pathways as well as anti-angiogenic activity.

XM_001096915

TNFRSF11B

Tumor necrosis factor receptor superfamily, member 11b

TNF receptor family inhibits apoptosis as decoy receptor for TRAIL.

XM_001082859

CASP9

Caspase 9, apoptosis-related cysteine peptidase

Pro-apoptotic by through activation of caspase cascade.

NM_001042733

IL6

Interleukin 6 (interferon, beta 2)

Pluripotent cytokine which is anti-apoptotic and pro-inflammatory in acute phase response

XM_001104328

ADORA1

Adenosine A1 receptor

Adenosine receptor inhibits adenylyl cyclase

XM_001085850

BCL2L10

BCL2-like 10 (apoptosis facilitator)

Inhibits apoptosis by preventing mitochondrial cytochrome C release.

NM_001032875

CCL20

Chemokine (C-C motif) ligand 20

Chemotaxis of dendritic cells, T-cells, and B-cells.

MIP-3α

XM_001083110

PXMP2

Peroxisomal membrane protein 2, 22kDa

Pore-forming activity in peroxisomal membrane

XM_001108040

BIK

BCL2-interacting killer (apoptosis-inducing)

Accelerates apoptosis

XM_001117272

LOC721200

Complement component 4A (Rodgers blood group)

Essential for the propagation of classical complement pathway and plays and major role infection diseases and inflammatory processes

XM_001118232

TNFRSF1A

Tumor necrosis factor receptor superfamily, member 1A

Primary receptor for TNFa and pro-apoptotic.

NM_001142873

MYC

V-myc myelocytomatosis viral oncogene homolog (avian)

Cell cycle progression and pro-apoptotic

NM_001047134

IL1R2

Interleukin 1 receptor, type II

Acts as decoy receptor for IL-1 and inhibits the activity of IL-1R1 ligands.

XM_001082504

IL17RB

Interleukin 17 receptor B

Induces production of IL-8

XM_001112911

TYMP

Thymidine phosphorylase

Promotes angiogenesis by proliferation of endothelial cells.

XM_001086840

APAF1

Apoptotic peptidase activating factor 1

Promotes apoptosis by binding cytochrome C and activates caspase cascade.

XM_001104160

BAG3

BCL2-associated athanogene 3

Anti-apoptotic and binds HSP70/HSC70.

XM_001107790

TNFRSF10A

Tumor necrosis factor receptor superfamily, member 10a

Receptor for TRAIL and induces apoptosis.

XM_001090833

CASP7

Caspase 7, apoptosis-related cysteine peptidase

Induces apoptosis

XM_001093641

IL-1F5

Interleukin 36 receptor antagonist

Inhibits NK-kB activation and prevents IL-36R signaling, and may activate anti-inflammatory pathway

XM_001109281

BCL2A1

BCL2-related protein A1

Inhibits apoptosis

XM_001091119

IL1F8

Interleukin 36, beta

Pro-inflammatory signaling through IL-1RL2 and IL-36R, present in epithelial barrers, and stimulates production of IL-6 and IL-8 and various chemokines.

XM_001100700

BLNK

B-cell linker

Involved in B-cell receptor signaling and activation of ERK/EPHB2, MAP, p38, AP1, NF-kB, and PLCG1 and 2 activation.

XM_001084983

DAPK1

Death-associated protein kinase 1

Mediates IFNg signaled cell death

XM_001099305

MGLL

Monoglyceride lipase

Metabolizes free fatty acids and glycerol, contributes to endocannabinoid signaling.

XM_001090430

ERBB2

V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Part of epidermal growth factor receptor family and enhances activation of MAP-K and PI3K signaling pathways.

NM_001032917

IL2RA

Interleukin 2 receptor, alpha

Part of IL-2 receptor family involved in mediating immune tolerance through regulatory T-cell activity.

XM_001092296

LEFTY2

Left-right determination factor 2

TGF-beta receptor ligand and activates SMAD signaling pathway.

XM_001090570

BAK1

BCL2-antagonist/ killer 1

Mediates mitochondrial release of cytochrome C and accelerates apoptosis.

XM_001089600

MAPK1

Mitogen-activated protein kinase 1

MAP kinase signaling transduction pathway involved in cell growth, adhesion, survival, and differentiation.

XM_001086237

BCL2L11

BCL2-like 11 (apoptosis facilitator)

Induces apoptosis through caspase mediated pathway

XM_001095097

CSF3

Colony stimulating factor 3 (granulocyte)

Granulocyte stimulating factor involved in production, differentiation, and function of Granulocytes.

G-CSF

NM_001032846

IL7

Interleukin 7

Pro-inflammatory cytokine involved in both B-cell differentiation and Th1 response.

XM_001117239

CRP

C-reactive protein, pentraxin-related

Acute phase reactant, part of pentaxin family and involved in agglutination, bacterial capsular swellilng, complement fixation, and phagocytosis.

XM_001104958

IFNK

Interferon, kappa

Type I interferon family and regulates immune cell function.

XM_001103515

PTX3

Pentraxin 3, long

Part of pentraxin protein family induced in inflammatory response and promotes fibrocyte differentiation, and involved in regulating inflammation and complement activation.

XM_001099255

SERPINA1

Serpin peptidase inhibitor, clade A (alpha-1 antiproteniase, antitrypsin), member 1

Proteolytic activity against plasmin, thrombin, trypsin, chymotrypsin, plasminogen activation, and decreases coagulation time.

XM_001101015

TNFSF18

Tumor necrosis factor receptor superfamily, member 18

Co-stimulator for T-cell activation and proliferation.

XM_001083745

OSMR

Oncostatin M receptor

Involved in IL-31 signaling and activation of STAT pathway.

XM_001108593

LIF-L

Leukemia inhibitory factor-like

Involved in cell death signaling pathway

XM_001100017

CXCR5

Chemokine (C-X-C motif) receptor 5

Chemoattractant for B-cells

XM_001106071

IL17B

Interleukin 17B

Pro-inflammatory and induces release of TNFa and IL-1b.

XM_001090729

INHBB

Inhibin, beta B

Part of TGF-beta family and involved in PEDF induced signaling and TGF-beta signaling pathways.

XM_001083817

PCGF2

Polycomb group ring finger 2

Negative regulatory of transcription for cell proliferation control, cytokines, chemokines, and chemokine receptors.

XM_001094967

SELE

Selectin E

Expressed by activated endothelial cells and involved in leukocyte trafficking

XM_001109474

EPHX2

Epoxide hydrolase 2, cytoplasmic

Involved in xenobiotic metabolism

NM_001032915

CXCL9

Macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Pro-inflammatory cytokine which counteracts effects of glucocorticoids, but also regulates regulate macrophage activity in host defense.

MIF

XM_001088935

CD70

CD70 antigen-like

Induces proliferation in activated T-cells, and further increases T-cell activation.

XM_001115079

RPL13A

Ribosomal protein L13A

Part of Gamma Interferon Inhibitor of Translocation complex functions to inhibit inflammatory response.

NM_001032821

CCL2

Chemokine (C-C motif) ligand 2

Chemotactic for monocytes and basophils, and augments monocyte activity.

MCP-1

XM_001094589

TRAP1

TNF receptor-associated protein 1

Encodes for heat shock proteins and interacts with TNF type I to regulate cellular stress response.

XM_001103121

LOC718480

Peptidoglycan recognition protein 1-like

Involved in TNF signaling pathway, also displays bactericidal activity toward Gram-positive and bacteriostatic activity activity toward Gram-positive.

PGLYRP

XM_001112492

LOC711637

Regenerating islet-derived protein 3-gamma-like

Bactericidal and bacteriostatic activity towards Gram-negative

REG3G

XM_001084526

CX3CR1

Chemokine (C-X3-C motif) receptor 1

Binds CX3CL1 and mediates both adhesive and migratory functions.

XM_001088286

HRH1

Histamine receptor H1

Mediates contraction of smooth muscle, and increases capillary permeability.

NM_001032848

GREM1

Gremlin 1

Inhibits monocyte chemotaxis.

XM_001101077

FIGF

C-fos induced growth factor (vascular endothelial growth factor D)

Promotes angiogenesis, lymphogenesis, and stimulates proliferation and migration of endothelial cells.

NM_001032950

CXCL11

Chemokine (C-X-C motif) ligand 11

Induced by IFN gamma, and is chemotactic for activated T-cells by binding CXC receptor 3.

I-TAC

XM_001088781

FOS

FBJ murine osteosarcoma viral oncogene homolog

Involved in cell proliferation and differentiation.

XM_001093896

IL23R

Interleukin 23 receptor

Mediates T-cell, NK cell, and myeloid cell stimulation.

XM_001104979

LOC708837

Similar to growth differentiation factor 9 precursor

A member of the transforming growth factor-β (TGF-β) superfamily,involved in ovarian folliculogenesis

XM_001084047

CCR8

Chemokine (C-C motif) receptor 8

Involved in monocyte chemotaxis