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Table 3 Differential expression of genes from injured lung tissue in comparison control non-injured lung tissue

From: Host responses to concurrent combined injuries in non-human primates

Accession No. Gene Symbol Gene Name Molecular Function Fold Change
NM_001047130 IL2 Interleukin 2 T-cell activation and proliferation, B-cell, NK cell, and monocyte activation 7798.12
XM_001093307 SPP1 Secreted phosphoprotein 1 Upregulation of inflammatory cytokines including IL-12 and Interferon Gamma 1139.76
XM_001110657 CXCL14 Chemokine (C-X-C motif) ligand 14 Chemotactic for monocytes 382.36
MIP-2γ
XM_001095645 MAL Mal, T-cell differentiation protein Endoplasmic reticulum protein likely associated with T-cell signal transduction 257.02
XM_001103106 PRG3 Proteoglycan 3 Stimulates neutrophil respiratory burst and IL-8 production, as well as basophil histamine and leukotriene C4 production. 202.97
XM_001101685 KNG1 Kininogen 1 Part of kallikrein blood coagulation and can be cleaved to produce bradykinin 86.68
XM_001092700 FGF10 Fibroblast growth factor 10 Involved in wound healing, and secreased by alveolar epithelial cells in response to injury. 81.64
XM_001094451 LBP Lipopolysaccharide binding protein Acute phase reactant to gram-negative bacteria and facilitates LPS binding to CD14 on monocytes. 63.00
XM_001108113 IFNW1 Interferon, omega 1 Involved in Toll-Like receptor Signaling Pathways and Type I interferon receptor binding. 47.27
XR_092351 LOC100426120 BCL2/adenovirus E18 19 kDa protein interacting protein 3-like BCL2 – Suppresses apoptosis by regulating mitochondrial membrane permeability and inhibits caspase activity. 46.51
XM_001112015 LTA Lymphotoxin alpha (TNF superfamily, member 1) Member of TNF family and mediates various inflammatory, immunostimulatory, and antiviral responses. 31.78
XM_001100604 BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 Inhibits cell death 31.56
XM_001110285 BCL2L1 BCL2-like 1 Regulates mitochondrial release of apoptotic factors 15.07
NM_001032946 CCL23 Chemokine (C-C motif) ligand 23 Potent chemotactic factor for monocytes, resting T-cells, and neutrophils. 23.81
MIP-3
XM_001107576 IFNA14 Interferon, alpha 14 Binds type interferon receptor and demonstrates anti-viral activity 19.58
XM_001107510 IL1R1 Interleukin 1 receptor, type I Mediates IL-1 dependent activation of NF-kappa-B and MAPK pathways. 18.46
XM_001087874 LOC699418 Eosinophil lysophospholipase-like Protecgt eosinophils from being lysed by large amounts of phospholipids 15.98
XM_001117159 IL22 Interleukin 22 Part of IL-10 family and initiates innate immune responses against bacteria in gut and respiratory epithelial cells. 14.93
XM_001110530 S100A8 S100 calcium binding protein A8 Involved in cell cycle progression and differentiation intracellularly as well as neutrophil chemotaxis, proinflammatory, pro-apoptotic, DAMP, and oxidant-scavening 12.67
XM_001108108 IL18RAP Interleukin 18 receptor accessory protein Enhances IL-18R signaling though PEDF induced signaling. 12.31
XM_00108022 PROK2 Prokineticin 2 Involved in circadian rhythm and gastrointestinal smooth muscle contraction. 10.89
XM_001113239 IL22RA1 Interleukin 22 receptor, alpha 1 Part of IL-10 receptor complex and induces JAK/STAT pathways as well as anti-angiogenic activity. 10.09
XM_001096915 TNFRSF11B Tumor necrosis factor receptor superfamily, member 11b TNF receptor family inhibits apoptosis as decoy receptor for TRAIL. 9.86
XM_001082859 CASP9 Caspase 9, apoptosis-related cysteine peptidase Pro-apoptotic by through activation of caspase cascade. 9.61
NM_001042733 IL6 Interleukin 6 (interferon, beta 2) Pluripotent cytokine which is anti-apoptotic and pro-inflammatory in acute phase response 9.28
XM_001104328 ADORA1 Adenosine A1 receptor Adenosine receptor inhibits adenylyl cyclase 9.27
XM_001085850 BCL2L10 BCL2-like 10 (apoptosis facilitator) Inhibits apoptosis by preventing mitochondrial cytochrome C release. 8.33
NM_001032875 CCL20 Chemokine (C-C motif) ligand 20 Chemotaxis of dendritic cells, T-cells, and B-cells. 7.60
MIP-3α
XM_001083110 PXMP2 Peroxisomal membrane protein 2, 22kDa Pore-forming activity in peroxisomal membrane 6.54
XM_001108040 BIK BCL2-interacting killer (apoptosis-inducing) Accelerates apoptosis 5.34
XM_001117272 LOC721200 Complement component 4A (Rodgers blood group) Essential for the propagation of classical complement pathway and plays and major role infection diseases and inflammatory processes 5.09
XM_001118232 TNFRSF1A Tumor necrosis factor receptor superfamily, member 1A Primary receptor for TNFa and pro-apoptotic. 5.01
NM_001142873 MYC V-myc myelocytomatosis viral oncogene homolog (avian) Cell cycle progression and pro-apoptotic 4.97
NM_001047134 IL1R2 Interleukin 1 receptor, type II Acts as decoy receptor for IL-1 and inhibits the activity of IL-1R1 ligands. 4.93
XM_001082504 IL17RB Interleukin 17 receptor B Induces production of IL-8 4.67
XM_001112911 TYMP Thymidine phosphorylase Promotes angiogenesis by proliferation of endothelial cells. 4.60
XM_001086840 APAF1 Apoptotic peptidase activating factor 1 Promotes apoptosis by binding cytochrome C and activates caspase cascade. 4.53
XM_001104160 BAG3 BCL2-associated athanogene 3 Anti-apoptotic and binds HSP70/HSC70. 4.36
XM_001107790 TNFRSF10A Tumor necrosis factor receptor superfamily, member 10a Receptor for TRAIL and induces apoptosis. 4.29
XM_001090833 CASP7 Caspase 7, apoptosis-related cysteine peptidase Induces apoptosis 4.20
XM_001093641 IL-1F5 Interleukin 36 receptor antagonist Inhibits NK-kB activation and prevents IL-36R signaling, and may activate anti-inflammatory pathway 4.05
XM_001109281 BCL2A1 BCL2-related protein A1 Inhibits apoptosis 3.86
XM_001091119 IL1F8 Interleukin 36, beta Pro-inflammatory signaling through IL-1RL2 and IL-36R, present in epithelial barrers, and stimulates production of IL-6 and IL-8 and various chemokines. 3.85
XM_001100700 BLNK B-cell linker Involved in B-cell receptor signaling and activation of ERK/EPHB2, MAP, p38, AP1, NF-kB, and PLCG1 and 2 activation. 3.78
XM_001084983 DAPK1 Death-associated protein kinase 1 Mediates IFNg signaled cell death 3.59
XM_001099305 MGLL Monoglyceride lipase Metabolizes free fatty acids and glycerol, contributes to endocannabinoid signaling. 3.56
XM_001090430 ERBB2 V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Part of epidermal growth factor receptor family and enhances activation of MAP-K and PI3K signaling pathways. 3.55
NM_001032917 IL2RA Interleukin 2 receptor, alpha Part of IL-2 receptor family involved in mediating immune tolerance through regulatory T-cell activity. 3.50
XM_001092296 LEFTY2 Left-right determination factor 2 TGF-beta receptor ligand and activates SMAD signaling pathway. 3.14
XM_001090570 BAK1 BCL2-antagonist/ killer 1 Mediates mitochondrial release of cytochrome C and accelerates apoptosis. 3.30
XM_001089600 MAPK1 Mitogen-activated protein kinase 1 MAP kinase signaling transduction pathway involved in cell growth, adhesion, survival, and differentiation. 3.04
XM_001086237 BCL2L11 BCL2-like 11 (apoptosis facilitator) Induces apoptosis through caspase mediated pathway 3.01
XM_001095097 CSF3 Colony stimulating factor 3 (granulocyte) Granulocyte stimulating factor involved in production, differentiation, and function of Granulocytes. 3.00
G-CSF
NM_001032846 IL7 Interleukin 7 Pro-inflammatory cytokine involved in both B-cell differentiation and Th1 response. 2.96
XM_001117239 CRP C-reactive protein, pentraxin-related Acute phase reactant, part of pentaxin family and involved in agglutination, bacterial capsular swellilng, complement fixation, and phagocytosis. 2.83
XM_001104958 IFNK Interferon, kappa Type I interferon family and regulates immune cell function. 2.81
XM_001103515 PTX3 Pentraxin 3, long Part of pentraxin protein family induced in inflammatory response and promotes fibrocyte differentiation, and involved in regulating inflammation and complement activation. 2.76
XM_001099255 SERPINA1 Serpin peptidase inhibitor, clade A (alpha-1 antiproteniase, antitrypsin), member 1 Proteolytic activity against plasmin, thrombin, trypsin, chymotrypsin, plasminogen activation, and decreases coagulation time. 2.72
XM_001101015 TNFSF18 Tumor necrosis factor receptor superfamily, member 18 Co-stimulator for T-cell activation and proliferation. 2.68
XM_001083745 OSMR Oncostatin M receptor Involved in IL-31 signaling and activation of STAT pathway. 2.62
XM_001108593 LIF-L Leukemia inhibitory factor-like Involved in cell death signaling pathway 2.58
XM_001100017 CXCR5 Chemokine (C-X-C motif) receptor 5 Chemoattractant for B-cells 2.56
XM_001106071 IL17B Interleukin 17B Pro-inflammatory and induces release of TNFa and IL-1b. 2.52
XM_001090729 INHBB Inhibin, beta B Part of TGF-beta family and involved in PEDF induced signaling and TGF-beta signaling pathways. 2.46
XM_001083817 PCGF2 Polycomb group ring finger 2 Negative regulatory of transcription for cell proliferation control, cytokines, chemokines, and chemokine receptors. 2.45
XM_001094967 SELE Selectin E Expressed by activated endothelial cells and involved in leukocyte trafficking 2.39
XM_001109474 EPHX2 Epoxide hydrolase 2, cytoplasmic Involved in xenobiotic metabolism 2.30
NM_001032915 CXCL9 Macrophage migration inhibitory factor (glycosylation-inhibiting factor) Pro-inflammatory cytokine which counteracts effects of glucocorticoids, but also regulates regulate macrophage activity in host defense. 2.29
MIF
XM_001088935 CD70 CD70 antigen-like Induces proliferation in activated T-cells, and further increases T-cell activation. 2.28
XM_001115079 RPL13A Ribosomal protein L13A Part of Gamma Interferon Inhibitor of Translocation complex functions to inhibit inflammatory response. 2.17
NM_001032821 CCL2 Chemokine (C-C motif) ligand 2 Chemotactic for monocytes and basophils, and augments monocyte activity. 2.17
MCP-1
XM_001094589 TRAP1 TNF receptor-associated protein 1 Encodes for heat shock proteins and interacts with TNF type I to regulate cellular stress response. 2.13
XM_001103121 LOC718480 Peptidoglycan recognition protein 1-like Involved in TNF signaling pathway, also displays bactericidal activity toward Gram-positive and bacteriostatic activity activity toward Gram-positive. 2.04
PGLYRP
XM_001112492 LOC711637 Regenerating islet-derived protein 3-gamma-like Bactericidal and bacteriostatic activity towards Gram-negative 0.25
REG3G
XM_001084526 CX3CR1 Chemokine (C-X3-C motif) receptor 1 Binds CX3CL1 and mediates both adhesive and migratory functions. 0.25
XM_001088286 HRH1 Histamine receptor H1 Mediates contraction of smooth muscle, and increases capillary permeability. 0.25
NM_001032848 GREM1 Gremlin 1 Inhibits monocyte chemotaxis. 0.23
XM_001101077 FIGF C-fos induced growth factor (vascular endothelial growth factor D) Promotes angiogenesis, lymphogenesis, and stimulates proliferation and migration of endothelial cells. 0.21
NM_001032950 CXCL11 Chemokine (C-X-C motif) ligand 11 Induced by IFN gamma, and is chemotactic for activated T-cells by binding CXC receptor 3. 0.21
I-TAC
XM_001088781 FOS FBJ murine osteosarcoma viral oncogene homolog Involved in cell proliferation and differentiation. 0.17
XM_001093896 IL23R Interleukin 23 receptor Mediates T-cell, NK cell, and myeloid cell stimulation. 0.14
XM_001104979 LOC708837 Similar to growth differentiation factor 9 precursor A member of the transforming growth factor-β (TGF-β) superfamily,involved in ovarian folliculogenesis 0.10
XM_001084047 CCR8 Chemokine (C-C motif) receptor 8 Involved in monocyte chemotaxis 0.03