Table 1 Gene ontology analysis for downregulated genes in the bronchiolar epithelium of bleomycin-treated mice with naphthalene-induced club cell injury compared to that without cell injury on day 14
From: Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice
Gene ontology term | Frequency (%) | P value | FDR (%) |
|---|---|---|---|
Biological process | |||
Response to wounding | 5.48 | 1.34 × 10−15 | 2.33 × 10−12 |
Inflammatory response | 3.75 | 1.41 × 10−11 | 2.47 × 10−8 |
Defense response | 4.90 | 3.28 × 10−8 | 5.75 × 10−5 |
Molecular function | |||
Chemokine activity | 1.25 | 1.68 × 10−7 | 2.52 × 10−4 |
Chemokine receptor binding | 1.25 | 2.32 × 10−7 | 3.48 × 10−4 |
Cytokine activity | 2.59 | 8.90 × 10−7 | 0.001 |
Biological process | |||
Chemotaxis | 2.02 | 2.52 × 10−7 | 4.42 × 10−4 |
Taxis | 2.02 | 2.52 × 10−7 | 4.42 × 10−4 |
Locomotory behavior | 2.69 | 3.99 × 10−5 | 0.070 |
Molecular function | |||
Serine-type endopeptidase inhibitor activity | 1.92 | 3.55 × 10−6 | 0.005 |
Endopeptidase inhibitor activity | 2.31 | 4.57 × 10−6 | 0.007 |
Peptidase inhibitor activity | 2.40 | 6.48 × 10−6 | 0.010 |
Enzyme inhibitor activity | 2.88 | 1.07 × 10−5 | 0.016 |