Fig. 4

Whole lung homogenates were obtained from the asthma model with and without MSCs or BMMs and evaluated for HA. Ovalbumin challenge mice had elevated HA (4a, p ≤ 0.05, n = 5). Treatment of the mice with 10⁶ hMSCs resulted in decreased levels of HA (4b, p ≤ 0.05, n = 5). Treatment by the control cells, in these studies bone marrow cells BMM, had no impact on the amount of challenge induced HA vertical lined bar. The saline group which received hMSCs had no change in HA levels. The bars in figure 4b represent statistical significant (Ova/Ova) differences in hyaluronan production. The first bar represents an increase in hyaluronan in OVA sensitized and OVA challenged mice vs. saline shame (light solid bar). The second bar represents a significant decrease in hyaluronan production in OVA sensitized/challenged mice who received hMSCs (cross-hatched bar)