Fig. 1
From: Interleukin-35 on B cell and T cell induction and regulation
IL-35 signal transduction in T and B cells. Signaling through gp130 or IL12Rb2 homodimers to STAT1 or STAT4 separately in T cells, while formation of the gp130/IL12Rb2 heterodimer is required for both STAT1 and STAT4 activation in Treg cells (left panel). B cells respond to IL-35 through the IL27Ra/IL12Rb2 heterodimer to STAT1 and STAT3 (right panel)