Fig. 1

TMP relieved mechanical allodynia in periorbital region in CCI mice. Controlled cortical impact (CCI) was performed on the surface of the somatosensory cortex in the right hemisphere. Periorbital thresholds in both ipsilateral (a) and (b) contralateral sides were measured with von Frey filament assay. Sham (solid circle), CCI (solid square) and CCI + 4 mM TMP (open circle) mice. n = 6 in each group. Data are presented as mean ± SEM values and representative of at least three independent experiments. * P < 0.05; ** P < 0.01, compared with CCI mice