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Fig. 6 | Journal of Inflammation

Fig. 6

From: Increased adipose tissue expression of TLR8 in obese individuals with or without type-2 diabetes: significance in metabolic inflammation

Fig. 6

TLR8 mRNA expression in the adipose tissue associates with local gene expression of TLR2, TLR4, and MyD88. The adipose tissue gene expression of TLR2, TLR4, TLR8, and MyD88 was determined in 49 non-diabetic and 45 type-2 diabetic (T2D) individuals by using quantitative real-time RT-PCR as described in Methods. The representative data from two independent determinations show that TLR8 gene expression was positively associated with that of (a) TLR2 (r = 0.55, P < 0.0001); (b) TLR4 (r = 0.28, approaching significance with P = 0.06); and (c) MyD88 (r = 0.55, P < 0.0001). Similarly, in T2D patients, TLR8 gene expression was found to be associated with (d) TLR2 (r = 0.76, P < 0.0001); (e) TLR4 (r = 0.66, P < 0.0001); and (f) MyD88 expression (r = 0.52, P = 0.0002). Due to missing data, TLR8 correlation with TLR4 is shown for 44 T2D patients

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