| | TNFα | IL-1β | IL-6 |
|---|
ISS | 0.24 ± 0.04a
| 4.9 ± 1.1a
| 0.2 ± 0.6a
|
Days after LPS treatment: |
2 | 0b
| 31.5 ± 4.3a
| 1.9 ± 1.4a
|
3 | 0b
| 18.8 ± 3.3a,b
| 0.2 ± 0.2a
|
† 4 | 3.5 ± 0.4a,c
| 112 ± 19.2c
| 46.2 ± 4.6b
|
- Mean ± SEM of brain cytokine levels in saline- or LPS-treated C57BL/6 J male mice (n = 5, † one mouse dead after LPS injection). Different literals a,b,cindicate significant differences in the level of each cytokine between saline-treated and 2, 3, and 4 days post-LPS treated mice using the Kruskal-Wallis test (non-parametric ANOVA), TNFα (p = 0.0004), IL-1β (p = 0.0003), IL-6 (p = 0.008). Data are from one out of three experiments
