Fig. 2

Experimental design line. a LPS or ISS were injected at day 0. The inflammatory peripheral and central status was evaluated before and at the different times after injection. b Electrodes were implanted at day 0. Five days later, mice were randomly divided into five groups: sham, isotonic saline solution treated mice (ISS), Vagus Nerve Stimulation (VNS), LPS and LPS + VNS