Fig. 4

The effect of systemic treatment with AM1030 in murine arthritis models. Systemic treatment with AM1030 reduced arthritis development in rat AIA (a, b) and mouse G6PI-induced arthritis (c) as compared to vehicle. In (a), once daily subcutaneous treatment with 30 mg/kg AM1030 (p = 0.06 vs. vehicle (20 % Solutol® HS15 in normal saline), n = 6/group). In (b), once daily peroral treatment with 1-10 mg/kg AM1030 in water (*p < 0.05 at 10 mg/kg, n = 6/group). In (c), once daily subcutaneous treatment with 30 mg/kg AM1030 (****p = 0.0001 vs. vehicle (20 % Solutol® HS15 in normal saline), n = 10/group). Joint swelling and arthritis score data obtained from each individual animal were summed for the whole evaluation period, after which the Mann-Whitney test (a, c) or the Kruskal-Wallis one-way ANOVA with Dunn’s post test (b) were used for statistical analysis