The effect of high glucose on the inhibitory action of C21, a selective AT2R agonist, of LPS-stimulated tissue factor expression in human mononuclear cells

Table 1 Resting and LPS(100 ng/ml)-stimulated Tissue Factor (TF) procoagulant activity (PCA), antigen(ag) and mRNA in normal (NG, 5.5 mM) and high (HG, 50.0 mM) glucose conditions

TF PCA (AU)
	NG	HG
Resting	0.0054 ± 0.003	0.035 ± 0.4*
LPS-stimulated (N = 33)	0.93 ± 0.36**	2.7 ± 1.1, *
TFAg (ng/mL)
Resting	32 ± 24	428 ± 135*
LPS-stimulated (N = 12)	1486 ± 388**	2652 ± 622, *
TF mRNA (normalized fold expression)
Resting	0.007 ± 0.003	0.158 ± 0.1*
LPS-stimulated (N = 8)	0.65 ± 0.5**	0.85 ± 0.5, *

ISSN: 1476-9255