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Fig. 9 | Journal of Inflammation

Fig. 9

From: Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance

Fig. 9

Production of TNF-α in the plasma of LPS-treated wild-type and CSE-/- mice during LPS tolerance. C57/J6 black wild type and CSE-/- mice were randomized into the following groups: C group: vehicle treatment; TD group: 1 mg/kg LPS during 3 days, followed by the induction of endotoxemia with 10 mg/kg LPS; D group: vehicle (instead of the tolerizing doses of LPS) before the challenge with 10 mg/kg LPS. Animals were euthanized at 4 (a) or 12 (b) hours after exposure to 10 mg/kg LPS. *p < 0.05 TD vs. D groups; #p < 0.05 shows the inhibitory effect of CSE deficiency, compared to the respective wild-type group

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