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Fig. 4 | Journal of Inflammation

Fig. 4

From: Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance

Fig. 4

H2S modulates the production of IL-6 in THP-1 cells treated with LPS. Macrophages were stimulated either with a single dose of LPS 0.5 μg/ml (T group), a single dose of LPS 0.5 μg/ml followed by a higher dose of LPS (1 μg/ml) (TD group) or directly with LPS (1 μg/ml) (D group). IL-6 concentration in the culture medium was measured after 4 h (a) or 24 h (b) after the final LPS treatment. The H2S biosynthesis inhibitor AOAA and the H2S donor were both applied at 1 mM. *p < 0.05 TD vs. D groups; #p < 0.05 shows the inhibitory effect of NaHS, compared to the respective group that did not receive the H2S donor

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