Fig. 2

ADC ROI mapping. a The ROI of reduced ADC, identified by thresholding, when it first becomes reduced (ROI_{6 h}) was mapped forwards onto original ADC maps at subsequent time points (in white). The ROI of reduced ADC at 24 h (ROI_{24 h}), the greatest area of ADC change, was mapped onto 6 h and 72 h ADC maps (in black). The ROIs of 6 h and 24 h time points are overlaid in the last row; the spatial difference representing the ADC of ROI_{6 h-24 h}. All images are from the same animal and are representative of the group. b Time course of development of the ADC of the ROI_{6 h}. Mean ADC (error bars indicate a 1 SD). c Time course of development of the ROI_{6 h-24 h} . Mean ADC (error bars indicate a 1 SD). Statistical significance indicated by ▲ p < 0.05; one-way ANOVA, post-testing using Bonferroni multiple comparisons test, with respect to the ADC at 6 h. IL-1β-injected animals, n = 6 at each time point