Skip to main content
Fig. 2 | Journal of Inflammation

Fig. 2

From: Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice

Fig. 2

Nur77−/− mice have increased susceptibility to LPS/D-GalN-induced acute liver injury. a H&E staining of livers from Nur77+/+ and Nur77−/− mice 5 h after injection with LPS/D-GalN. Representative images are shown. Scale bars, 100 μM. Original magnification, 100x. b Liver extracts assessed by Western blot and indicated antibodies. c ELISA of serum ALT and AST from Nur77+/+ and Nur77−/− mice 5 h after injection with LPS/D-GalN or PBS. Error bars represent means ± SD. *p < 0.05 and **p < 0.01. d Tnf, Il6 and Il12 mRNA expression was measured with RT-PCR (left) and qPCR (right) in livers from Nur77+/+ and Nur77−/− mice 2 h after treatment with LPS/D-GalN. Error bars represent means ± SD from 3 biological replicates. *p < 0.05 and **p < 0.01. e ELISA quantification of serum TNFα, IL-6 from Nur77+/+ and Nur77−/− mice after treatment with LPS/D-GalN for 5 h. Error bars represent means ± SD. *p < 0.05

Back to article page