Fig. 1

Structural similarities of CXCL11, CXCL12 and CXCL14. a CXCL11, CXCL12 and CXCL14 are all small chemokines with a similar molecular structure. The three chemokines all share a C-terminal α-helix and comprise high pI values. Structures of the molecules were obtained by RCSB protein data bank and pdb-files were displayed with Jmol: an open-source Java viewer for chemical structures in 3D. http://www.jmol.org/. b CXCL11, CXCL12 and CXCL14 share high amino acid sequence conservation with 4 cysteines, 2 lysines and 1 proline residue being conserved throughout all 3 chemokines (conserved amino acids shown by asterisk *). Alignment was performed using Clustal Omega multiple sequence alignment tool. (References: [12, 65–67])