Table 3 Association between CD4+, CD8+ and Foxp3+CD4+ T cells number within cancer islets and stroma and clinicopathological charateristics
CD4+ T cells median, (range) | CD8+ T cells median, (range) | Foxp3+CD4+ T cells median, (range) | ||||
|---|---|---|---|---|---|---|
Islets | Stroma | Islets | Stroma | Islets | Stroma | |
Gender: | ||||||
Female | 27 (11–74) | 162 (99–421) | 35.5 (16–138) | 181.5 (76–319) | 12.5 (0–27) | 44.5 (11–69) |
Male | 18 (11–82) | 222 (98–489) | 39 (10–219) | 218 (80–374) | 12 (1–35) | 41 (12–72) |
Smoking status: | ||||||
Smokers | 18 (11–82) | 239 (98–489)** | 38 (10–219) | 223 (80–374)** | 11.5 (0–27) | 42.5 (11–63) |
Non-smokers | 34 (11–74) | 138.5 (99–221) | 34.5 (16–111) | 162 (76–290) | 12 (1–35) | 41 (12–72) |
Histological NSCLC type: | ||||||
Adenocarcinoma | 17.5 (11–80) | 187 (98–458)*,** | 39 (10–151) | 201.5 (111–374) | 11.5 (0–27) | 41 (11–69) |
Squamous cell carcinoma | 18.5 (11–82) | 261 (105–489) | 36.5 (15–219) | 226 (80–362) | 13 (3–35) | 41 (13–72) |
Other | 42 (15–57) | 127.5 (101–392) | 39.5 (16–86) | 241 (76–324) | 11.5 (1–24) | 30.5 (12–63) |
pT status | ||||||
pT1a-2b | 19.5 (11–82) | 209 (101–489) | 38 (15–151) | 206 (76–369) | 12.5 (0–32) | 44 (11–72) |
pT3-4 | 19.5 (12–69) | 213 (98–453) | 38 (10–219) | 225.5 (115–374) | 11.5 (1–35) | 40 (13–63) |
Lymph node status: | ||||||
Negative (N0) | 22 (11–78) | 215 (98–444) | 39 (10–142) | 189 (80–374)** | 11 (0–35) | 42 (11–63) |
Positive (N1-N3) | 17 (12–82) | 205 (99–489) | 37 (15–219) | 229 (76–369) | 13 (1–32) | 41 (12–72) |
Diferenciation: | ||||||
Poor | 19.5 (11–82) | 223 (98–458) | 35.5 (10–219) | 207.5 (80–374) | 13 (0–35) | 40 (11–69) |
Other | 18 (11–69) | 189 (101–489) | 39 (15–111) | 210 (76–324) | 12 (1–25) | 43 (12–72) |
COPD: | ||||||
Present | 21.5 (11–80) | 191.5 (98–458) | 40 (16–219)** | 196 (76–374)** | 12 (0–35) | 40.5 (11–63) |
Absent | 17 (11–82) | 266 (109–489) | 34.5 (10–75) | 240.5 (101–369) | 12 (3–25) | 42.5 (13–72) |