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Table 3 Association between CD4+, CD8+ and Foxp3+CD4+ T cells number within cancer islets and stroma and clinicopathological charateristics

From: The prognostic influence of tumor infiltrating Foxp3+CD4+, CD4+ and CD8+ T cells in resected non-small cell lung cancer

  CD4+ T cells median, (range) CD8+ T cells median, (range) Foxp3+CD4+ T cells median, (range)
Islets Stroma Islets Stroma Islets Stroma
Gender:       
 Female 27 (11–74) 162 (99–421) 35.5 (16–138) 181.5 (76–319) 12.5 (0–27) 44.5 (11–69)
 Male 18 (11–82) 222 (98–489) 39 (10–219) 218 (80–374) 12 (1–35) 41 (12–72)
Smoking status:       
 Smokers 18 (11–82) 239 (98–489)** 38 (10–219) 223 (80–374)** 11.5 (0–27) 42.5 (11–63)
 Non-smokers 34 (11–74) 138.5 (99–221) 34.5 (16–111) 162 (76–290) 12 (1–35) 41 (12–72)
Histological NSCLC type:       
 Adenocarcinoma 17.5 (11–80) 187 (98–458)*,** 39 (10–151) 201.5 (111–374) 11.5 (0–27) 41 (11–69)
 Squamous cell carcinoma 18.5 (11–82) 261 (105–489) 36.5 (15–219) 226 (80–362) 13 (3–35) 41 (13–72)
 Other 42 (15–57) 127.5 (101–392) 39.5 (16–86) 241 (76–324) 11.5 (1–24) 30.5 (12–63)
pT status       
 pT1a-2b 19.5 (11–82) 209 (101–489) 38 (15–151) 206 (76–369) 12.5 (0–32) 44 (11–72)
 pT3-4 19.5 (12–69) 213 (98–453) 38 (10–219) 225.5 (115–374) 11.5 (1–35) 40 (13–63)
Lymph node status:       
 Negative (N0) 22 (11–78) 215 (98–444) 39 (10–142) 189 (80–374)** 11 (0–35) 42 (11–63)
 Positive (N1-N3) 17 (12–82) 205 (99–489) 37 (15–219) 229 (76–369) 13 (1–32) 41 (12–72)
Diferenciation:       
 Poor 19.5 (11–82) 223 (98–458) 35.5 (10–219) 207.5 (80–374) 13 (0–35) 40 (11–69)
 Other 18 (11–69) 189 (101–489) 39 (15–111) 210 (76–324) 12 (1–25) 43 (12–72)
COPD:       
 Present 21.5 (11–80) 191.5 (98–458) 40 (16–219)** 196 (76–374)** 12 (0–35) 40.5 (11–63)
 Absent 17 (11–82) 266 (109–489) 34.5 (10–75) 240.5 (101–369) 12 (3–25) 42.5 (13–72)
  1. *P < 0.05, Kruskal-Wallis test
  2. **P < 0.05, Mann–Whitney test