E-selectin and vascular cell adhesion molecule-1 as biomarkers of 3-month outcome in cerebrovascular diseases

Journal of Inflammation

Table 2 Biomarkers with significant higher levels in patients with 3-month poor outcome, univariate and ROC analysis

Biomarker	Comparison mean concentrations+/−SD			ROC curves		Univariate analysis
Time	Good outcome	Poor outcome	p ^a	AUC (95 % CI)	Cut-off	OR (95 % CI)	p ^b
E-selectin
0–6 h	26 ± 15 ng/mL	41 ± 19 ng/mL	0.004	78 % (61–95)	29 ng/mL	26 (4–165)	0.001
VCAM-1
2–3 weeks	669 ± 197 ng/mL	886 ± 284 ng/mL	0.003	73 % (59–88)	820 ng/mL	9 (3–33)	0.001
CRP
6–36 h	6 ± 13 mg/L	18 ± 26 mg/L	0.003	75 % (62–88)	5 mg/L	6 (2–18)	0.005
2–3 days	9 ± 15 mg/L	54 ± 68 mg/L	<0.001	83 % (74–92)	7 mg/L	15 (4–49)	<0.001
5–7 days	15 ± 53 mg/L	72 ± 101 mg/L	<0.001	81 % (71–91)	9 mg/L	9 (3–26)	<0.001
IL-6
2–3 days	50 ± 209 pg/mL	193 ± 819 pg/mL	<0.001	75 % (64–87)	14 pg/mL	9 (3–25)	<0.001
5–7 days	70 ± 274 pg/mL	21 ± 20 pg/mL	0.004	70 % (58–82)	4 pg/mL	12 (3–54)	0.002
NT-proBNP
6–36 h	1135 ± 2215 pg/mL	2547 ± 3286 pg/mL	0.002	76 % (65–88)	413 pg/mL	24 (3–200)	0.003
2–3 days	1254 ± 2235 pg/mL	3899 ± 7161 pg/mL	0.001	73 % (62–84)	314 pg/mL	18 (4–82)	<0.001
5–7 days	1134 ± 2736 pg/mL	2055 ± 2557 pg/mL	0.001	73 % (62–84)	272 pg/mL	9 (3–26)	<0.001
S100B
2–3 days	31 ± 57 pg/mL	336 ± 566 pg/mL	0.003	70 % (57–83)	30 pg/mL	5 (2–13)	0.001

SD standard deviation, ROC receiver operating characteristic analysis, AUC area under the curve, OR odds ratio, 95 % CI 95 % confidence interval; poor outcome defined as modified Rankin Scale score > 2
^aComparison of biomarkers levels between both groups, good and poor outcome, with Mann–Whitney U test, level of significance with Bonferroni correction (p < 0.005)
^bUnivariate analysis performed for biomarkers after determination of cut-off using ROC analysis

ISSN: 1476-9255