Fig. 3

IL-18 is expressed primarily by endothelial cells. Transmission electron microscopy images of damaged piriform cortex shows IL-18 expression associated with endothelial cells (a-d). Expression was observed around damaged endothelial connections (a, open arrow), on the luminal surface (b), in the cell body (c) and at intracellular junctions of endothelial cells (d). (ec = endothelial cell, bl = basal lamina, ij = intracellular junction. Scale bar: 1 μm [a], 0.2 μm [b-d]; n = 3)