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Fig. 2 | Journal of Inflammation

Fig. 2

From: Interleukin-18 expression increases in response to neurovascular damage following soman-induced status epilepticus in rats

Fig. 2

IL-18 expression is associated with vascular structures in injured brain regions. Tissue sections at 48 h were labeled with anti-IL-18 antibody along with cell type-specific antibodies. IL-18 immunolabeling (a-i, green) is present in the piriform cortex, hippocampus and thalamus following GD-induced SE (a, b & c; left) but absent in vehicle controls (a, b & c; right). IL-18 labeling was associated with the neurovascular unit, though labeling was predominantly co-incident with these immunolabels. Neurons (d, red) and vasculature-associated astrocytes (e, red) had rare and non-contiguous co-localization. Labeling was absent in microglia (f, red) and smooth muscle (g, red). Consistent co-incident labeling of IL-18 was present near pericytes (h, red) and endothelial cells (i, red). DAPI (a-h, blue) was used to label the nuclei of cells. (Scale bar: 250 μm [a-c], 50 μm for fluorescent and 5 μm [d-i] for confocal microscopy; n = 3 for 48-h, n = 4 for vehicle controls)

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