Fig. 2
From: Nur77 deficiency leads to systemic inflammation in elderly mice
Nur77 deficiency in mice enhances the production of pro-inflammatory cytokines and immunoglobulin. (a) qRT-PCR analysis of the expression of Tnfα and Il6 mRNA in liver and spleen samples from 8-monthold Nur77+/+ and Nur77−/− mice (n = 6 per group). Error bars represent mean ± s.d. from n = 3 biological triplicates. *p < 0.05 and **p < 0.01. (b) ELISA assay of IL-6 concentration in serum from 8-month-old Nur77+/+ and Nur77−/− mice (n = 6 per group). Error bars represent mean ± s.d. from n = 3 biological triplicates. **p < 0.01. (c) Titers of IgG1 and IgE in serum from 8-month-old Nur77+/+ and Nur77−/− mice (n = 6 per group). Error bars represent mean ± s.d. from n = 3 biological triplicates. **p < 0.01