Table 3 Cytokine levels obtained in the 22 SLE patients and 10 healthy individuals
HC n = 10 | ISLE n = 11 | ASLE n = 11 | P value significance | ||
|---|---|---|---|---|---|
IL-17A | Cytokine level (pg/mL) | 0.0 (0.0–0.0): 0.00 | 0.0 (0.0–113.40): 12.69 | 0.0 (0.0–62.04): 9.28 | ns |
% of samples detected (n) | 0 % (n = 0) | 18.2 % (n = 2) | 27.3 % (n = 3) | ns | |
IL-17E | Cytokine level (pg/mL) | 0.0 (0.0–286.21): 81.27 | 0.0 (0.0–1364.68): 159.38 | 0.0 (0.0–57.10): 5.19 | ns |
% of samples detected (n) | 30 % (n = 3) | 18.2 % (n = 2) | 9.1 % (n = 1) | ns | |
IL-17F | Cytokine level (pg/mL) | 0.0 (0.0–14.49): 3.93 | 0.0 (0.00–158.44): 19.10 | 0.0 (0.0–57.10): 5.19 | ns |
% of samples detected (n) | 30 % (n = 3) | 27.3 % (n = 3) | 9.1 % (n = 1) | ns | |
IL-12p70 | Cytokine level (pg/mL) | 0.0 (0.0–46.87): 6.98 | 0.96 (0.0–60.76): 8.05 | 0.0 (0.0–85.52): 8.85 | ns |
% of samples detected (n) | 30 % (n = 3) | 54.5 % (n = 6) | 36.4 % (n = 4) | ns | |
IL-23 | Cytokine level (pg/mL) | 0.0 (0.0–1134.54): 276.46 | 0.0 (0.0–11221.86): 1216.17 | 0.0 (0.0–2547.96): 258.94 | ns |
% of samples detected (n) | 30 % (n = 3) | 18.2 % (n = 2) | 18.2 % (n = 2) | ns | |
TNF-α | Cytokine level (pg/mL) | 7.68 (6.25–33.50): 12.38 | 13.57 (4.30–26.73): 13.66 | 14.51 (1.01–27.90): 16.47 | ns |
% of samples detected (n) | 100 % (n = 10) | 100 % (n = 11) | 100 % (n = 11) | ns | |
IFN-γ | Cytokine level (pg/mL) | 0.0 (0.0–8.96): 2.95 | 0.0 (0.0–167.11): 21.90 | 2.77 (0.0–79.40): 12.36 | ns |
% of samples detected (n) | 40 % (n = 4) | 27.3 % (n = 3) | 63.6 % (n = 7) | ns | |
IL-15 | Cytokine level (pg/mL) | 0.0 (0.0–0.0): 0.0 | 0.0 (0.0–7.45): 1.41 | 0.0 (0.0–0.0): 0.0 | ns |
% of samples detected (n) | 0 % (n = 0) | 18.2 % (n = 2) | 0 % (n = 0) | ns | |
IL-10 | Cytokine level (pg/mL) | 0.0 (0.0–0.0): 0.0 | 0.0 (0.0–6.58): 0.99 | 0.0 (0.0–5.36): 0.89 | ns |
% of samples detected (n) | 0 % (n = 0) | 100 % (n = 11) | 100 % (n = 11) | ns | |
IL-22 | Cytokine level (pg/mL) | 0.0 (0.0–100.8): 18.77 | 0.0 (0.0–598.67): 64.06 | 0.0 (0.0–159.85): 14.53 | ns |
% of samples detected (n) | 30 % (n = 3) | 18.2 % (n = 2) | 9.1 % (n = 1) | ns | |
IL-21 | Cytokine level (pg/mL) | 0.0 (0.0–5.61): 0.80 | 0.0 (0.0–105.58): 12.13 | 0.0 (0.0–24.07): 2.68 | ns |
% of samples detected (n) | 10 % (n = 1) | 18.2 % (n = 2) | 18.2 % (n = 2) | ns | |
IL-13 | Cytokine level (pg/mL) | 0.0 (0.0–0.0): 0.0 | 0.0 (0.0–56.44): 6.76 | 0.0 (0.0–0.0): 0.0 | ns |
% of samples detected (n) | 0 % (n = 0) | 18.8 % (n = 2) | 0 % (n = 0) | ns | |