Adipokine gene expression in peripheral blood of adult and juvenile dermatomyositis patients and their relation to clinical parameters and disease activity measures

Table 3 Differences in peripheral blood and muscle gene expression levels of adipokines between juvenile dermatomyositis patients and non-disease pediatric controls*

	Peripheral blood			Muscle
	JDM (N = 26)	Non-disease pediatric controls (N = 6)	P Value	JDM (N = 7)	Non-disease pediatric controls (N = 5)	P Value
Leptin	1.2 (1.0, 1.6)	1.3 (0.7, 2.8)	0.96	0.6 (0.3, 1.3)	1.4 (0.5, 1.9)	0.37
Adiponectin	0.1 (0.1, 0.2)	1.2 (0.1, 4.0)	0.014	2.6 (0.4, 7.7)	1.3 (0.8, 2.0)	0.46
Resistin	0.9 (0.6, 1.5)	1.0 (0.7, 1.5)	0.60	15.9 (10.5, 18.4)	2.6 (2.5, 7.4)	0.012
Visfatin	1.4 (1.0, 2.1)	2.1 (1.7, 2.5)	0.05	2.0 (1.4, 3.0)	1.0 (1.0, 1.1)	0.028
IL-6	1.2 (0.8, 1.5)	1.2 (0.6, 1.6)	0.92	1.6 (0.7, 1.7)	1.0 (0.8, 1.1)	0.22
TNF-α	0.6 (0.4, 0.7)	1.0 (0.9, 1.4)	<0.001	2.2 (1.1, 3.0)	1.0 (0.9, 1.2)	0.09

*Values are presented as median (25^th percentile, 75^th percentile). Gene expression levels of adipokines were normalized to the mean of age-matched controls. P-value is from Wilcoxon rank sum test.

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