Figure 2

Increased activation of NF-κB in progressive ASVD lesions. A. Activated NF-κB-p65 detected in the intima of aortas with PIT or FA by immunostaining with anti phospho S536. Sample with AIT did not show activation of NF-κB Magnifications as indicated. B. Box-plot showing percentage of cells with activated NF-κB in the intima, regarding the total number of cells in the field, according to histological lesion. Kruskal-Wallis test. C.- Activated NF-κB-p65 detected in the adventitia of aortas with PIT or FA by immunostaining with anti-phospho S536. Activation of NF-κB was detected in endothelial cells (ECs), smooth muscle cells (SMCs) and lymphocytes (L). Sample with AIT did not show activation of NF-κB. Magnifications as indicated. D.- Box-plot showing percentage of cells with activated NF-κB in the adventitia, regarding the total number of cells in the field, according to histological lesion. Kruskal-Wallis test.