Expression of hedgehog signal pathway in articular cartilage is associated with the severity of cartilage damage in rats with adjuvant-induced arthritis

Table 3 Correlations between mRNA levels of Shh, Ptch1, Smo and Gli1 in articular cartilage and the severity of cartilage damage in AIA rats (n = 15), indicated by OARSI scores on articular cartilage, COII and aggrecan mRNA levels in articular cartilage

mRNA levels		Shh	Ptch1	Smo	Gli1
OARSI scores	r	0.561 (*)	0.346	0.489	0.565(*)
OARSI scores	p	0.029	0.207	0.064	0.028
COII mRNA levels	r	−0.680 (**)	−0.572 (*)	−0.533 (*)	−0.587 (*)
COII mRNA levels	p	0.005	0.026	0.033	0.021
Aggrecan mRNA levels	r	−0.576 (*)	−0.590 (**)	−0.353	−0.765 (**)
Aggrecan mRNA levels	p	0.025	0.021	0.197	0.001

The correlation analysis was performed by the Pearson’s correlation test. Asterisks (*) show the significance of the correlation (two tails). ^* p < 0.05; ^** p < 0.01.

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