Figure 5

Chronic intermittent hypobaric hypoxia pretreatment decreases HIF-1α and NF-κB protein expression of synovial tissue in collagen-induced arthritis rat. Chronic intermittent hypobaric hypoxia (CIHH) pretreatment prevented the protein over expression of HIF-1α (A) and NF-κB (B) in synovial tissue of collagen-induced arthritis rat. Representative photographs of protein expression in synovial tissue by western blots technique (above); Summaries of densitometric scanning of protein normalized to GADPH (bottom); CIA: collagen-induced arthritis groups; CIHH + CIA: CIHH pretreatment group; Data were expressed as mean ± SEM, n = 6 for each group, * P < 0.05 vs CIA,# P < 0.05 vs Control.