CLA inhibits production of pro-inflammatory citokine secretion in human macrophages and foam cells. Measurement of cytokine released was quantified in HPBMC-derived (a) macrophages and (b) foam cells following treatment with c-9,t-11; t-10,c-12; CLA blend; OA; LA or TROG using a multiplex ELISA. Both individual CLA isomers and the CLA bend reduced pro-inflammatory cytokine generation via a PPARγ dependent mechanisms. Uniquely, c-9,t-11-CLA increased macrophage and foam cell generation of IL10, via a PPARγ independent mechanism. Data are expressed as % cytokine release over vehicle control and are the mean of three independent experiments where *p < 0.05, **p < 0.01, ***p < 0.001.