Figure 3From: Inflammation contributes to NKX3.1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression Overexpression of NKX3.1 leads to the suppression of oxidative stress. A. The CM (250 pg/ml of TNFα for 24 h)-mediated increase in GPX2 and SOD2 expression is upregulated upon NKX3.1 overexpression in LNCaP cells. B. The H2O2-induced intracellular ROS level is suppressed by NKX3.1. Control and NKX3.1-expressing constructs (pcDNA4-HM) were transfected into the cells 24 h prior to H2O2 treatment, p < 0.001.Back to article page