Overexpression of NKX3.1 leads to the suppression of oxidative stress. A. The CM (250 pg/ml of TNFα for 24 h)-mediated increase in GPX2 and SOD2 expression is upregulated upon NKX3.1 overexpression in LNCaP cells. B. The H2O2-induced intracellular ROS level is suppressed by NKX3.1. Control and NKX3.1-expressing constructs (pcDNA4-HM) were transfected into the cells 24 h prior to H2O2 treatment, p < 0.001.