Figure 1

Antioxidant LNAC treatment restores AR, NKX3.1 and p53 expression levels. In LNCaP cells, the expression levels that were reduced by treatment with A. CM (including 125 and 250 pg/ml of TNFα) and B. H₂O₂ (250 μM) for 24 h were partially restored back to control expression levels by the antioxidant LNAC (10 mM) treatment. LNAC was applied to the cells 1 h prior to the addition of CM or H₂O₂. C. AR depletion together with CM treatment reduced the NKX3.1 level. CM: conditioned media.