Figure 2

Anti-DNAM-1 monoclonal antibody does not protect from the development of collagen-induced arthritis at US assessment. (a) Examples of picture of the knees in B-mode assessment in mice injected with anti-DNAM1 (n = 7) (B-mode score = 0.5), those treated with control IgG antibody (n = 7) (B-mode score = 1.5) , those injected with PBS (n = 7) (B-mode score = 1.5) and control non-immunized mice (n = 6) (B-mode score = 0). (b) B-mode score was not significantly different between the three groups, despite a trend for lower scores in mice injected with anti-DNAM-1. (c) Examples of picture of inflammatory synovitis at Doppler assessment in tarsus of the three groups of mice (Doppler score = 1 in mice injected with anti-DNAM-1, whereas it was equal to 2 in the other groups). Example of Doppler assessment in tarsus of non-immunized mice (Doppler score = 0 in all 6 non-immunized mice). To note, there are artefacts signals Doppler on bone. (d) Doppler score was not significantly different between the three groups, despite a trend for lower scores in mice injected with anti-DNAM-1.Values are the median ± IQR.